What's new in the Aire?

  title={What's new in the Aire?},
  author={Mickie H Cheng and Anthony K. Shum and Mark S. Anderson},
  journal={Trends in immunology},
  volume={28 7},
Unraveling the mechanisms underlying autoimmune disease remains a difficult challenge. Recent lessons learned from the study of AIRE (autoimmune regulator), the gene responsible for the rare monogenic human syndrome APS-1, highlight the power of genetics to reveal disease pathogenesis. With the discovery of AIRE, central tolerance has re-emerged as a crucial check against autoimmunity. Aire-mediated regulation of diverse self-antigens in the thymus serves as a paradigm for the importance of… CONTINUE READING