What's in the pipeline? New immunosuppressive drugs in transplantation.

@article{Vincenti2002WhatsIT,
  title={What's in the pipeline? New immunosuppressive drugs in transplantation.},
  author={Flavio Vincenti},
  journal={American journal of transplantation : official journal of the American Society of Transplantation and the American Society of Transplant Surgeons},
  year={2002},
  volume={2 10},
  pages={
          898-903
        }
}
In the pipeline, there are a number of novel immunosuppressive drugs in preclinical development or in early clinical trials. The major target of new agents are cell-surface molecules important in immune cell interactions (especially the costimulatory pathway), signaling pathways that activate T cells, T-cell proliferation and trafficking and recruitment of immune cells responsible for rejection. The most promising biologic agents include a humanized anti-CD11a (anti-LFA1), humanized anti-B7.1… CONTINUE READING

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