What's in a drop? Correlating observations and outcomes to guide macromolecular crystallization experiments.
@article{Luft2011WhatsIA, title={What's in a drop? Correlating observations and outcomes to guide macromolecular crystallization experiments.}, author={Joseph R. Luft and Jennifer R. Wolfley and Edward H. Snell}, journal={Crystal growth \& design}, year={2011}, volume={11 3}, pages={ 651-663 } }
Observations of crystallization experiments are classified as specific outcomes and integrated through a phase diagram to visualize solubility and thereby direct subsequent experiments. Specific examples are taken from our high-throughput crystallization laboratory which provided a broad scope of data from 20 million crystallization experiments on 12,500 different biological macromolecules. The methods and rationale are broadly and generally applicable in any crystallization laboratory. Through…
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