Wf-536 prevents tumor metastasis by inhibiting both tumor motility and angiogenic actions.

@article{Nakajima2003Wf536PT,
  title={Wf-536 prevents tumor metastasis by inhibiting both tumor motility and angiogenic actions.},
  author={Masahide Nakajima and Kazutaka Hayashi and Ken-ichi Katayama and Yusaku Amano and Yasuhiro Egi and Masayoshi Uehata and Nobuharu Goto and Takao Kondo},
  journal={European journal of pharmacology},
  year={2003},
  volume={459 2-3},
  pages={
          113-20
        }
}
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68 Citations

The Rho kinase inhibitor fasudil inhibits tumor progression in human and rat tumor models

Fasudil, an orally available inhibitor of Rho kinases, and its metabolite 1-(hydroxy-5-isoquinoline sulfonyl-homopiperazine) (fasUDil-OH) modify tumor cell morphology and inhibit tumor cell migration and anchorage-independent growth.

Antitumoral effect of a selective Rho-kinase inhibitor Y-27632 against Ehrlich ascites carcinoma in mice.

The Rho kinase inhibitor fasudil inhibits the migratory behaviour of 95-D lung carcinoma cells.

Loss of RhoA expression prevents proliferation and metastasis of SPCA1 lung cancer cells in vitro.

RhoA inhibits apoptosis and increases proliferation of cultured SPCA1 lung cancer cells

It is suggested that RhoA knockdown prevents cell proliferation and induces apoptosis in SPCA1 lung cancer cells, and the underlying mechanisms responsible for these effects may include the activation of caspase-3 and the reduction of phospho-STAT3 levels.

The Rho-kinase inhibitor inhibits proliferation and metastasis of small cell lung cancer.

Effect of fasudil on growth, adhesion, invasion, and migration of 95D lung carcinoma cells in vitro.

The Rho-kinase inhibitor prevents the growth, adhesion, invasion, and migration of 95D lung carcinoma cells by inhibiting the Rho/Rho-Kinase pathway.

Rho Kinase Inhibitor Fasudil Suppresses the Vasculogenic Mimicry of B16 Mouse Melanoma Cells Both In Vitro and In Vivo

Investigating the biologic role of the Rho kinase inhibitor fasudil in the vasculogenic mimicry (VM) of B16 mouse melanoma cells and exploring the effect of RhoA and Rho-associated, coiled-coil containing protein kinase (ROCK) on VM formation suggest that fasUDil may be an emerging therapeutic option for targeting cancer VM.

Rho/ROCK signaling in motility and metastasis of gastric cancer.

This review discusses Rho GTPases and ROCK signaling and describes the mechanisms of Rho/ROCK activity with regard to motility and metastasis in gastric cancer and provides an insight of the therapeutic potential of targeting the Rho-associated protein kinases pathway.

6-Substituted purines as ROCK inhibitors with anti-metastatic activity.

...

References

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Y‐27632, an Inhibitor of Rho‐associated Protein Kinase, Suppresses Tumor Cell Invasion via Regulation of Focal Adhesion and Focal Adhesion Kinase

Y‐27632 suppressed LPA‐induced tyrosine phosphorylation of FAK and paxillin, suggesting that ROCK regulates these molecules and Y‐276 32 inhibits cellular migration and morphological change, at least in part, through this regulation.

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