Wet harvesting of no-carrier-added 211At from an irradiated 209Bi target for radiopharmaceutical applications

  title={Wet harvesting of no-carrier-added 211At from an irradiated 209Bi target for radiopharmaceutical applications},
  author={Alexander T. Yordanov and Oscar R. Pozzi and Sean Carlin and Gamal Akabani and B. Wieland and Michael R Zalutsky},
  journal={Journal of Radioanalytical and Nuclear Chemistry},
Astatine-211 is one of the most promising α-emitters for targeted cancer radiotherapy. However, research and clinical trials involving 211At-labeled radiopharmaceuticals have often been impeded due to the irregular and sometimes inconveniently low recovery yields obtained by the currently used dry distillation procedure. Therefore, a wet harvesting procedure isolating 211At from an irradiated 209Bi target was explored. The procedure involves target dissolution in concentrated HNO3 and… 

Production of [(211)At]-astatinated radiopharmaceuticals and applications in targeted α-particle therapy.

Several compounds have shown high potential for the treatment of cancers in vitro and in several animal models, thus providing a promising basis that has allowed initiation of the first two clinical studies of astatine-biomolecule bond.

Evaluation of a Wet Chemistry Method for Isolation of Cyclotron Produced [211At]Astatine

A “wet chemistry” approach for isolation of 211At from an irradiated bismuth target is described. The approach involves five steps: (1) dissolution of bismuth target in conc. HNO3; (2) removal of the

Astatine-211: production and availability.

The 7.2-h half life radiohalogen (211)At offers many potential advantages for targeted α-particle therapy; however, its use for this purpose is constrained by its limited availability. Astatine-211

Extraction of 211At from nitric acid solutions into various organic solvents for use as an α-source for radiation chemistry studies

Abstract The partitioning of 211At from an irradiated bismuth target using solvent extraction into several organic solvents is presented. Although astatine speciation is difficult to measure given

Géométries, electronic structures, and physico-chemical porperties of astatine species : an application of relativistic quantum mechanics

Les tentatives menees pour detruire des cellules cancereuses avec les agents radiotherapeutiques a base de 211 At qui ont ete synthetises jusqu’a present ne sont pas encore pleinement satisfaisantes