Wet granulation in a twin-screw extruder: implications of screw design.

Abstract

Wet granulation in twin-screw extrusion machinery is an attractive technology for the continuous processing of pharmaceuticals. The performance of this machinery is integrally tied to its screw design yet little fundamental knowledge exists in this emerging field for granulation to intelligently create, troubleshoot, and scale-up such processes. This study… (More)
DOI: 10.1002/jps.21973

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