Western blot mapping of disease-specific amyloid in various animal species and humans with transmissible spongiform encephalopathies using a high-yield purification method.

@article{Beekes1995WesternBM,
  title={Western blot mapping of disease-specific amyloid in various animal species and humans with transmissible spongiform encephalopathies using a high-yield purification method.},
  author={Michael Beekes and Erwin Baldauf and S Cassens and Heino Diringer and Paul H Keyes and Anthony C. Scott and Gerald A. H. Wells and Paul Brown and Clarence J. Gibbs and D. Carleton Gajdusek},
  journal={The Journal of general virology},
  year={1995},
  volume={76 ( Pt 10)},
  pages={2567-76}
}
SAF-protein, an amyloid, is the main constituent of scrapie-associated fibrils (SAF) and a specific marker for transmissible spongiform encephalopathies (TSE). Using an improved extraction method and Western blot detection, the disease-specific amyloid was found in various parts of the central nervous system of hamsters orally infected with scrapie, of squirrel monkeys orally infected with kuru, sporadic Creutzfeldt-Jakob disease (CJD) and scrapie, of human patients with sporadic CJD, of a… CONTINUE READING

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References

Publications referenced by this paper.
Showing 1-10 of 76 references

A review of the detection ofPrP sc

  • J. HOPE
  • Kluwer Academics
  • 1994

Antigenic sites of bovine priori protein

  • C. BIRKETT, C. BOSTOCK, R. H. MELOEN
  • Ref. : F.II.3JC/0003),
  • 1994

The nature of the scrapie agent: the virus theory

  • U.
  • Annals of the New York Academy of Sciences 724…
  • 1994

Structural studies

  • L A., S. B. PRUSlNER
  • 1993

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