Western Database of Lipid Variants (WDLV): a catalogue of genetic variants in monogenic dyslipidemias.

@article{Fu2013WesternDO,
  title={Western Database of Lipid Variants (WDLV): a catalogue of genetic variants in monogenic dyslipidemias.},
  author={Jennifer Qifang Fu and Samantha Kwok and Leah Sinai and Omar Abdel-Razek and Janet Babula and Dennis Chen and Emma Farago and Nigel Fernandopulle and Sean J. Leith and Melissa N. Loyzer and Catherine Lu and Niyati Malkani and Nicole Morris and Mandi K Schmidt and Randa L Stringer and Heather N. Whitehead and Matthew R. Ban and Joseph L. B. Dube and Adam D Mcintyre and Christopher Johansen and Henian Cao and Jian Wang and Robert A Hegele},
  journal={The Canadian journal of cardiology},
  year={2013},
  volume={29 8},
  pages={934-9}
}
BACKGROUND Next-generation sequencing (NGS) is nearing routine clinical application, especially for diagnosis of rare monogenic cardiovascular diseases. But NGS uncovers so much variation in an individual genome that filtering steps are required to streamline data management. The first step is to determine whether a potential disease-causing variant has been observed previously in affected patients. METHODS To facilitate this step for lipid disorders, we developed the Western Database of… CONTINUE READING

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