West Nile virus neutralization by US plasma-derived immunoglobulin products.

  title={West Nile virus neutralization by US plasma-derived immunoglobulin products.},
  author={Christina B. Planitzer and Jens Modrof and Thomas R. Kreil},
  journal={The Journal of infectious diseases},
  volume={196 3},
The 1999 introduction of West Nile virus (WNV) into the United States has resulted in the largest epidemic of arboviral illness in the Western Hemisphere, with an estimated 2.5 million cases of mostly asymptomatic human infections since then. As a consequence, an increasing occurrence of WNV antibodies in plasma collected in the United States, and thus in intravenous immunoglobulin (IVIG) products, can be expected. Using an in vitro assay to investigate antibody function, rather then presence… CONTINUE READING


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