West Nile virus-induced interferon production is mediated by the double-stranded RNA-dependent protein kinase PKR.

@article{Gilfoy2007WestNV,
  title={West Nile virus-induced interferon production is mediated by the double-stranded RNA-dependent protein kinase PKR.},
  author={Felicia D Gilfoy and Peter W. Mason},
  journal={Journal of virology},
  year={2007},
  volume={81 20},
  pages={
          11148-58
        }
}
Cells carry a variety of molecules, referred to as pathogen recognition receptors (PRRs), which are able to sense invading pathogens. Interaction of PRRs with viral compounds instigates a signaling pathway(s), resulting in the activation of genes, including those for type I interferon (IFN), which are critical for an effective antiviral response. Here we demonstrate that the double-stranded RNA (dsRNA)-dependent protein kinase PKR, which has been shown to function as a PRR in cells treated with… CONTINUE READING

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