West Nile virus-induced disruption of the blood-brain barrier in mice is characterized by the degradation of the junctional complex proteins and increase in multiple matrix metalloproteinases.

@article{Roe2012WestNV,
  title={West Nile virus-induced disruption of the blood-brain barrier in mice is characterized by the degradation of the junctional complex proteins and increase in multiple matrix metalloproteinases.},
  author={Kelsey Roe and M. M. Swathanthira Kumar and Stephanie Lum and Beverly Orillo and Vivek R Nerurkar and Saguna Verma},
  journal={The Journal of general virology},
  year={2012},
  volume={93 Pt 6},
  pages={
          1193-203
        }
}
West Nile virus (WNV) encephalitis is characterized by neuroinflammation, neuronal loss and blood-brain barrier (BBB) disruption. However, the mechanisms associated with the BBB disruption are unclear. Complex interactions between the tight junction proteins (TJP) and the adherens junction proteins (AJP) of the brain microvascular endothelial cells are responsible for maintaining the BBB integrity. Herein, we characterized the relationship between the BBB disruption and expression kinetics of… CONTINUE READING

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