West Nile virus-induced bax-dependent apoptosis.

  title={West Nile virus-induced bax-dependent apoptosis.},
  author={Maria del Carmen Parquet and Atsushi Kumatori and Futoshi Hasebe and Kouichi Morita and Akira Igarashi},
  journal={FEBS letters},
  volume={500 1-2},
The mechanism of cell death induced by West Nile virus (WNV), a causative agent of human febrile syndrome and encephalitis, was investigated. WNV-infected K562 and Neuro-2a cells manifested the typical features of apoptosis, including cell shrinkage, chromatin condensation and subdiploid DNA content by flow cytometry. DNA fragmentation into nucleosomal size and changes in outer cell membrane phospholipid composition were also observed in K562 cells. UV-inactivated virus failed to induce the… CONTINUE READING

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