West Nile virus genome amplification requires the functional activities of the proteasome.

@article{Gilfoy2009WestNV,
  title={West Nile virus genome amplification requires the functional activities of the proteasome.},
  author={Felicia D. Gilfoy and Rafik Fayzulin and Peter W. Mason},
  journal={Virology},
  year={2009},
  volume={385 1},
  pages={74-84}
}
The lifecycle of intracellular pathogens, especially viruses, is intimately tied to the macromolecular synthetic processes of their host cell. In the case of positive-stranded RNA viruses, the ability to translate and, thus, replicate their infecting genome is dependent upon hijacking host proteins. To identify proteins that participate in West Nile virus (WNV) replication, we tested the ability of siRNAs designed to knock-down the expression of a large subset of human genes to interfere with… CONTINUE READING