West Nile virus core protein; tetramer structure and ribbon formation.

@article{Dokland2004WestNV,
  title={West Nile virus core protein; tetramer structure and ribbon formation.},
  author={Terje Dokland and Martin Walsh and Jason M Mackenzie and Alexander A Khromykh and Kim-Huey Ee and Sifang Wang},
  journal={Structure},
  year={2004},
  volume={12 7},
  pages={1157-63}
}
We have determined the crystal structure of the core (C) protein from the Kunjin subtype of West Nile virus (WNV), closely related to the NY99 strain of WNV, currently a major health threat in the U.S. WNV is a member of the Flaviviridae family of enveloped RNA viruses that contains many important human pathogens. The C protein is associated with the RNA genome and forms the internal core which is surrounded by the envelope in the virion. The C protein structure contains four alpha helices and… CONTINUE READING