West Nile Virus Infection Causes Endocytosis of a Specific Subset of Tight Junction Membrane Proteins

@inproceedings{Xu2012WestNV,
  title={West Nile Virus Infection Causes Endocytosis of a Specific Subset of Tight Junction Membrane Proteins},
  author={Zaikun Xu and Regula Waeckerlin and Matt D. Urbanowski and Guido van Marle and Tom C Hobman},
  booktitle={PloS one},
  year={2012}
}
West Nile virus (WNV) is a blood-borne pathogen that causes systemic infections and serious neurological disease in human and animals. The most common route of infection is mosquito bites and therefore, the virus must cross a number of polarized cell layers to gain access to organ tissue and the central nervous system. Resistance to trans-cellular movement of macromolecules between epithelial and endothelial cells is mediated by tight junction complexes. While a number of recent studies have… CONTINUE READING
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