Werner syndrome protein participates in a complex with RAD51, RAD54, RAD54B and ATR in response to ICL-induced replication arrest

  title={Werner syndrome protein participates in a complex with RAD51, RAD54, RAD54B and ATR in response to ICL-induced replication arrest},
  author={M. Otterlei and P. Bruheim and B. Ahn and W. Bussen and P. Karmakar and K. Baynton and V. Bohr},
  journal={Journal of Cell Science},
  pages={5137 - 5146}
  • M. Otterlei, P. Bruheim, +4 authors V. Bohr
  • Published 2006
  • Biology, Medicine
  • Journal of Cell Science
  • Werner syndrome (WS) is a rare genetic disorder characterized by genomic instability caused by defects in the WRN gene encoding a member of the human RecQ helicase family. RecQ helicases are involved in several DNA metabolic pathways including homologous recombination (HR) processes during repair of stalled replication forks. Following introduction of interstrand DNA crosslinks (ICL), WRN relocated from nucleoli to arrested replication forks in the nucleoplasm where it interacted with the HR… CONTINUE READING
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