Werner syndrome protein interacts with human flap endonuclease 1 and stimulates its cleavage activity.

@article{Brosh2001WernerSP,
  title={Werner syndrome protein interacts with human flap endonuclease 1 and stimulates its cleavage activity.},
  author={Robert M. Brosh and Cayetano von Kobbe and Joshua A Sommers and Parimal Karmakar and Patricia L Opresko and Jason J. Piotrowski and Irina I. Dianova and Grigory L Dianov and Vilhelm A. Bohr},
  journal={The EMBO journal},
  year={2001},
  volume={20 20},
  pages={
          5791-801
        }
}
Werner syndrome (WS) is a human premature aging disorder characterized by chromosomal instability. The cellular defects of WS presumably reflect compromised or aberrant function of a DNA metabolic pathway that under normal circumstances confers stability to the genome. We report a novel interaction of the WRN gene product with the human 5' flap endonuclease/5'-3' exonuclease (FEN-1), a DNA structure-specific nuclease implicated in DNA replication, recombination and repair. WS protein (WRN… CONTINUE READING

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