Werner syndrome exonuclease catalyzes structure-dependent degradation of DNA.

@article{Shen2000WernerSE,
  title={Werner syndrome exonuclease catalyzes structure-dependent degradation of DNA.},
  author={J C Shen and L. A. Loeb},
  journal={Nucleic acids research},
  year={2000},
  volume={28 17},
  pages={3260-8}
}
Werner syndrome (WS) is an autosomal recessive disease characterized by early onset of many features of aging, by an unusual spectrum of cancers, and by genomic instability. The WS protein (WRN) possesses 3'-->5' DNA helicase and associated ATPase activities, as well as 3'-->5' DNA exonuclease activity. Currently, WRN is the only member of the widely distributed RecQ DNA helicase family with documented exonuclease activity. It is not known whether deficiency of the exonuclease or helicase… CONTINUE READING