Werner's syndrome protein is phosphorylated in an ATR/ATM-dependent manner following replication arrest and DNA damage induced during the S phase of the cell cycle

Abstract

Werner's syndrome (WS) is an autosomal recessive disorder, characterized at the cellular level by genomic instability in the form of variegated translocation mosaicism and extensive deletions. Individuals with WS prematurely develop multiple age-related pathologies and exhibit increased incidence of cancer. WRN, the gene defective in WS, encodes a 160-kDa… (More)
DOI: 10.1038/sj.onc.1206169

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@article{Pichierri2003WernersSP, title={Werner's syndrome protein is phosphorylated in an ATR/ATM-dependent manner following replication arrest and DNA damage induced during the S phase of the cell cycle}, author={Pietro Pichierri and Filippo Rosselli and Annapaola Franchitto}, journal={Oncogene}, year={2003}, volume={22}, pages={1491-1500} }