Wenjing decoction (herbal medicine) for the treatment of primary dysmenorrhea: a systematic review and meta-analysis

  title={Wenjing decoction (herbal medicine) for the treatment of primary dysmenorrhea: a systematic review and meta-analysis},
  author={Li-Xing Gao and Chunhua Jia and Hengyi Zhang and Cuilan Ma},
  journal={Archives of Gynecology and Obstetrics},
PurposeWenjing decoction is a well-accepted traditional Chinese medicine for the treatment of primary dysmenorrhea in East Asia, but its clinical effectiveness and risk have not been adequately assessed. In this paper, we conducted a systematic review and meta-analysis to evaluate the efficacy of Wenjing decoction for the treatment of primary dysmenorrhea.MethodsEight databases were used in our research: the Cochrane Library, the Web of Science, PubMed, EMBASE, the Chinese Biomedical Literature… 
Herbal medicine (Hyeolbuchukeo-tang or Xuefu Zhuyu decoction) for treating primary dysmenorrhea
The efficacy of XZD on primary dysmenorrhea is not conclusive owing to the small number of studies and the high risk of bias, and large-scale, long-term RCTs with rigorous methodological input are needed to clarify the role ofXZD for the management of primary dys menorrhea.
A comparison of the efficacy of Chinese herbal medicines in the treatment of primary dysmenorrhea
A network meta-analysis to systematically compare the advantages of different CHM in the treatment of primary dysmenorrhea is conducted and the completed NMA will be published in a peer-reviewed scientific journal.
Assessment of clinical efficacy of traditional Chinese medicine for the management of primary dysmenorrhea in the UK
The findings of this study will determine whether or not TCM is effective and safe for the treatment of PD in UK.
Guizhi Fuling Capsule Exhibits Antidysmenorrhea Activity by Inhibition of Cyclooxygenase Activity
  • Weiran Zheng, M. Li, W. Xiao
  • Medicine, Biology
    Evidence-based complementary and alternative medicine : eCAM
  • 2020
The study not only links GZFLc antidysmenorrhea activity to COX2 inhibition but also uncovers a mechanism of action by which an assay can be developed for bioefficacy evaluation of GZ FLc.
Effect of herb-partitioned moxibustion for primary dysmenorrhea: a randomized clinical trial.
Herb-partitioned moxibustion reduced menstrual pain and improved quality of life, these were sustained for up to 3 months after treatment.
Network Pharmacology Strategy to Investigate the Pharmacological Mechanism of Siwu Decoction on Primary Dysmenorrhea and Molecular Docking Verification
The pharmacological mechanisms of Siwu decoction (SWD) that act on primary dysmenorrhea (PDM) were investigated, and the active compounds in the SWD for treating PDM were further verified.
Prevalence of dysmenorrhea and predictors of its pain intensity among Palestinian female university students
There is a high proportion of dysmenorrhea among Palestinian female university students, and skipping breakfast was the strongest predictor for moderate/severe dysmenorrhic pain.
Proteomics analysis of differentially-expressed proteins in uterus of primary dysmenorrhea mice following administration of nuangong zhitong
Findings provide further insights into the mechanism underlying the protective effects of NZD, and STRING analysis indicated a total of 53 DEPs have direct or indirect functional links.
Prevalence of dysmenorrhea and determinants of pain intensity among university age women.
High levels of stress and early menarche were the potent determinants of moderate/severe dysmenorrhic pain among university students that disturb the quality of life.


A Randomised Placebo-Controlled Trial of a Traditional Chinese Herbal Formula in the Treatment of Primary Dysmenorrhoea
Four-Agents-Decoction (Si Wu Tang) therapy in this pilot post-market clinical trial, while meeting the standards of conventional medicine, showed no statistically significant difference in reducing menstrual pain intensity of primary dysmenorrhoea at the end of treatment.
Inhibitory effects of active fraction and its main components of Shaofu Zhuyu decoction on uterus contraction.
It is implied that Shaofu Zhuyu decoction may have direct inhibitory effects on the contractility of the mice uterus and justified the traditional use of the prescription for treating the uterine cramping associated dysmenorrhea.
Therapeutic effect of acupuncture on the outcomes of in vitro fertilization: a systematic review and meta-analysis
Based on an analysis of the studies, acupuncture improves the CPR among women undergoing IVF, and Optimal positive effects could be expected using acupuncture in IVF during COH, especially in Asian area.
The effect of fennel on pain quality, symptoms, and menstrual duration in primary dysmenorrhea.
Serum heme oxygenase-1 levels in patients with primary dysmenorrhea
Serum HO1, NO and MDA levels increase in patients with primary dysmenorrhea andAntioxidant support might be helpful to reduce pain severity in primary dys menorrhea.
Prevalence of primary dysmenorrhea in young adult female university students
It was established that although the rate of consultation with health professionals about menstruation and related changes was low, use of agents known to be effective in primary dysmenorrhea treatment was highly common.
Menstrual characteristics and prevalence of dysmenorrhea in college going girls
Dysmenorrhea is found to be highly prevalent among college going girls and family history, bleeding duration and presence of clots were significant risk factors for dysmenorhea.
Diagnosis and initial management of dysmenorrhea.
Dysmenorrhea is one of the most common causes of pelvic pain and it negatively affects patients' quality of life and sometimes results in activity restriction; however, there is not enough evidence to support the use of yoga, acupuncture, or massage.