Wellington: a novel method for the accurate identification of digital genomic footprints from DNase-seq data

@inproceedings{Piper2013WellingtonAN,
  title={Wellington: a novel method for the accurate identification of digital genomic footprints from DNase-seq data},
  author={Jason D Piper and Markus C. Elze and Pierre Cauchy and Peter N. Cockerill and Constanze Bonifer and Sascha Ott},
  booktitle={Nucleic acids research},
  year={2013}
}
The expression of eukaryotic genes is regulated by cis-regulatory elements such as promoters and enhancers, which bind sequence-specific DNA-binding proteins. One of the great challenges in the gene regulation field is to characterise these elements. This involves the identification of transcription factor (TF) binding sites within regulatory elements that are occupied in a defined regulatory context. Digestion with DNase and the subsequent analysis of regions protected from cleavage (DNase… CONTINUE READING
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