Well-Differentiated Fetal Adenocarcinoma: Rare Tumor in the Pediatric Population

Well-Differentiated Fetal Adenocarcinoma: Rare Tumor in the Pediatric Population},
  author={Megan J Difurio and Aaron Auerbach and Keith J. Kaplan},
  journal={Pediatric and Developmental Pathology},
Well-differentiated fetal adenocarcinoma (WDFA) is a rare tumor of the lung, which has gone by many names over the years. The lesion was first described by Kradin et al., in 1982, who called it “pulmonary blastoma with argyrophil cells and lacking sarcomatous features (pulmonary endodermal tumor resembling fetal lung).” Since then, there have been at least 65 cases reported in the literature. Although there has been no consensus in the literature as to the best pathological term for this entity… 
Well-differentiated fetal adenocarcinoma of the lung: clinicopathologic features of 45 cases in China.
WDFA is very different to conventional adenocarcinoma in clinicopathology, it prefers to occur in the second and third decades, and Beta-catenin may be a potential marker for disease.
Well-differentiated fetal adenocarcinoma of the lung in a 20-year-old woman.
WDFA is a rare pulmonary neoplasm resembling fetal lung and classified as a variant of adenocarcinoma, which occurs in younger people more often than the other histological types of primary lung cancer.
Well‐differentiated fetal adenocarcinoma of the lung mimicking adenoid cystic carcinoma on fine needle aspiration: A case report
The fine needle aspiration findings of a case of well‐differentiated fetal adenocarcinoma of the lung in a 44‐year‐old man with an incidental lung nodule revealed three‐dimensional clusters of epithelial cells with scant cytoplasm, hyperchromatic nuclei that are associated with an extracellular metachromatic matrix.
Adenocarcinoma of the Lung in Childhood and Adolescence: A Systematic Review
Biphasic Tumors of the Lungs
Based on their distinct morphological features and the results of the latest molecular investigations indicating tumor autonomy, these neoplasms warrant inclusion as independent entities.
Primary epithelial lung malignancies in the pediatric population
The Memorial Sloan‐Kettering Cancer Center experience with primary epithelial lung malignancies was reviewed to better understand their histology, time to diagnosis, treatment, and outcome.
Analysis of inconsistencies in terminology of spinal and bulbar muscular atrophy and its effect on retrieval of research.
  • Shelley Arvin
  • Medicine, Biology
    Journal of the Medical Library Association : JMLA
  • 2013
The author was engaged in a research project to create a comprehensive bibliography of the rare disease spinal and bulbar muscular atrophy (SBMA), and utilized a strategy to identify all of the various names for the disease.
A Case of Well-differentiated Fetal Adenocarcinoma Diagnosed in a 15-year-old Girl
背景.高分化胎児型腺癌(well-differentiated fetal adenocarcinoma:WDFA)は胎児肺の腺管に類似する稀な肺原発悪性腫瘍である.症例.15歳女性.高校入学時の健康診断で胸部異常陰影を指摘された.胸部CTで右肺下葉に境界明瞭な55×45


Pulmonary blastomas
The idea that histologic class and gross and clinical findings can be of prognostic value in pulmonary blastoma is supported, and the presence of thoracic adenopathy by chest radiography and metastasis at initial presentation were the factors most highly correlated with poor prognosis.
Six cases of well-differentiated adenocarcinoma simulating fetal lung tubules in pseudoglandular stage: Comparison with pulmonary blastoma
Six cases of well-differentiated adenocarcinoma resembling fetal lung were studied histologically, immunohistochemically, and ultrastructurally, and compared with three cases of pulmonary blastoma and may be a tumor with one-sided development of pulmonary Blastoma showing only an epithelial component.
Pulmonary adenocarcinomas of the fetal lung type: a clinicopathologic study indicating differences in histology, epidemiology, and natural history of low-grade and high-grade forms.
The H-FLAC represents the prototype of so-called pulmonary blastoma predominantly seen in the elderly, whereas L- FLAC and its biphasic form predominate in the middle-aged population.
Pleuropulmonary blastoma the so‐called pulmonary blastoma of childhood
The designation of pleuropulmonary blastoma is suggested by the authors for these intrathoracic neoplasms of childhood rather than pulmonary blastoma for histogenetic and anatomic reasons.
Endobronchial adenocarcinoma with endometrioid features and prominent neuroendocrine differentiation. A variant of fetal adenocarcinoma
It is demonstrated that fetal adenocarcinoma may occur as a central endobronchial mass and express a variable degree of neuroendocrine differentiation.
Polypoid pulmonary endodermal tumor resembling fetal lung: report of a case.
  • P. B. Babycos, P. Daroca
  • Medicine
    Modern pathology : an official journal of the United States and Canadian Academy of Pathology, Inc
  • 1995
A case of pulmonary endodermal tumor resembling fetal lung presenting as a polypoid intrabronchial mass is reported, usually peripheral in location, and rarely does this tumor present intrabronschially.
Pulmonary blastoma with argyrophil cells and lacking sarcomatous features (pulmonary endodermal tumor resembling fetal lung).
A tumor of the lung in a 35-year-old woman contained numerous complex, branching tubules resembling the developing fetal lung in its canalicular state, suggesting an endodermal origin for this neoplasm.
Pulmonary endodermal tumor resembling fetal lung. Report of a case with immunohistochemical studies.
A tumor of a 12-year-old boy was studied immunohistochemically by utilizing an extensive battery of antisera against active amines and peptides to support the probable derivation of the tumor from bronchopulmonary endocrine cells.
Pulmonary adenocarcinoma of fetal type: alternating differentiation argues in favour of a common endodermal stem cell
The light-microscopical, ultrastructural and immunhistochemical features of a newly defined type of pulmonary adenocarcinoma that resembles an early stage of lung differentiation, which speaks in favour of a common endodermal stem cell for the different types of epithelial cells within the lung, including endocrine cells.