Well‐formed cerebellum and brainstem‐like structures in a mature ovarian teratoma: Neuropathological observations

  title={Well‐formed cerebellum and brainstem‐like structures in a mature ovarian teratoma: Neuropathological observations},
  author={Masayuki Shintaku and Toshiko Sakuma and Chiho Ohbayashi and Motoyoshi Maruo},
  pages={122 - 128}
In the surgical case of a mature cystic teratoma of the ovary that arose in a 16‐year‐old girl, a large amount of well‐differentiated and highly organized cerebellar tissue was found. Three layers of the cerebellar cortex were well formed, and synaptophysin‐positive “glomeruli” were found in the granule cell layer. Some Purkinje cells exhibited focal expansion and a dysmorphic appearance of the dendrites. Adjacent to the cerebellar tissue, a large space lined by the ependymal layer and a club… 
1 Citations

Well-differentiated cerebellum in an ovarian mature cystic teratoma: a case report and review of the literature

This case of well-differentiated cerebellum within ovarian teratoma is reported to expand the pool of cases reported in literature of this extremely rare entity, as only 22 cases with such findings have been reported in Literature to the best of the knowledge.



Ovarian Mature Cystic Teratoma Exhibiting Well-Differentiated Cerebellum in a14-Year-Old Female

Mature cystic ovarian teratomas are commonly benign ovarian tumors that account for about 33% of all ovarian neoplasms and occasionally neuroectodermal derivates may be present, including mature glial tissue and other well-organized neural structures.

Central neurocytoma arising within a mature cystic teratoma of the ovary.

The case of a 23-year-old woman with a central neurocytoma arising in an otherwise mature cystic teratoma of the ovary remains well and free of tumor 1 year after cystectomy, in keeping with favorable follow-up data for surgically excised central neuro Cytomas within the brain.

Formation of “neo-cortex” in a congenital human teratoma

A congenital human teratoma contained a neuroectodermal mass with architectonic features similar to those of the normal developing neo-cortex, and may have been a critical determinant in the formation of the “cortical plate”.

Ovarian fetiform teratoma (homunculus) in a 9-year-old girl.

  • T. AbbottW. J. HermannR. Scully
  • Medicine
    International journal of gynecological pathology : official journal of the International Society of Gynecological Pathologists
  • 1984
This patient is one of the youngest reported with an ovarian homunculus or fetiform teratoma and reflects the highest degree of organized development exhibited by a single germ cell undergoing neoplasia.

Corpora amylacea in a mature cystic teratoma of the ovary

  • M. Shintaku
  • Medicine
    Neuropathology : official journal of the Japanese Society of Neuropathology
  • 2005
A large cystic tumor was removed from the right ovary of a 51-year-old woman with a 2-year history of lower abdominal fullness, and it exhibited typical pathological features of mature cystic teratoma (dermoid cyst).

Meningothelial Proliferations in Mature Cystic Teratom of the Ovary: Evidence for the Common Presence of Cranially Derived Tissues Paralleling Anterior Embryonic Plate Development. An Analysis of 25 Consecutive Cases

The similar morphologic appearance of the meningothelial proliferation in MCT to EMH, its localization to the dermal subcutaneous portion of MCT, and its frequent proximity to glial tissue supports the hypothesis that the tissue elements of ovarian MCT are primarily of the head and neck type.

Ovarian teratoma: Ultrastructure and neural component

The ultrastructural details of a malignant recurrent polycystic teratoma of the ovary in a child are presented and the perfect replication of brain, even to the blood‐glial relationships and synapses, is documented.

Structure of an isolated cerebellum and related nuclei developed within the matrix of a mature ovarian teratoma

It is postulated that a neuroectodermal germinal locus with proliferation capability similar to that found in the alar plates of the normal embryonic rhombencephalon was responsible for the formation of this highly organized neural tissue.

CNS Myelin and Synapses in a Spontaneous Mouse Ovarian Teratoma Showing Neural Differentiation: An Immunohistochemical and Electron Microscopic Study

  • C. Pappas
  • Biology
    Journal of neuropathology and experimental neurology
  • 1981
A morphologic (light, electron microscopic, and immunohistochemical) study of a spontaneous ovarian teratoma has revealed an unusually large number of mature myelinated axons and synapses within areas of well-differentiated neuroepithelium.

Extracerebral ectopic mass with huge cysts in the anterior cranial cavity

An unusual example of malformation in a 9‐day‐old‐girl, in whom an extracerebral ectopic mass with cysts was found in the anterior cranial cavity, is reported.