Well‐differentiated fetal adenocarcinoma of the lung: Cytomorphologic features on fine‐needle aspiration with emphasis on use of β‐catenin as a useful diagnostic marker

  title={Well‐differentiated fetal adenocarcinoma of the lung: Cytomorphologic features on fine‐needle aspiration with emphasis on use of $\beta$‐catenin as a useful diagnostic marker},
  author={L. Proctor and Andrew L Folpe and Annette M. Esper and Linda L. Wolfenden and Seth Daniel Force and Sanjay Logani},
  journal={Diagnostic Cytopathology},
Well‐differentiated fetal adenocarcinoma (WDFA), also known as low grade adenocarcinoma of the fetal lung type, is a rare pulmonary neoplasm now considered to be a variant of lung adenocarcinoma rather than a type of pulmonary blastoma. Upregulation of the Wnt signaling pathway with subsequent aberrant nuclear/cytoplasmic β‐catenin expression has been recently described in these tumors providing a possible pathogenetic role for this gene in WDFA. We describe the cytomorphologic findings of a… 
Aspiration cytomorphology of fetal adenocarcinoma of the lung.
Cytomorphologic attributes included small, uniform, round nuclei; morules; and neuroendocrine differentiation in glandular epithelial cells; Immunochemically, all tumors manifested epithelial and neuro endocrine differentiation.
Well-differentiated fetal adenocarcinoma of the lung: positron emission tomography features and diagnostic difficulties in frozen section analysis—a case report
A rare case of well-differentiated fetal adenocarcinoma of the lung that was difficult to diagnose based on radiological evaluations including FDG-PET and intraoperatively diagnosed using frozen section analysis is reported.
A 31-Year-Old Man with Well-differentiated Fetal Adenocarcinoma
This article reports a patient who was found to have a well-differentiated fetal type adenocarcinoma, following left lower lobectomy, believing that the identification of this cancer subtype in patients with lung carcinoma will reduce unnecessary radical treatment methods beyond surgery.
肺胎児型腺癌の 1 例
A case of fetal adenocarcinoma of the lung in a 70-year-old woman whose bronchial washing cytology showed many large overlapping palisaded tumor cell clusters is reported, which suggests that fetalAdenocARCinoma shows a variety of clusters in bronchials cytology.
Cytohistology of papillary carcinoid and emerging concept of pulmonary neuroendocrine neoplasms
The clinical, cytologic and histologic features of a morphologic variant of pulmonary carcinoid tumor forming exclusively of papillae, and the new findings in cell biology and molecular biology that led to the emerging concept that carcinoids and high‐grade neuroendocrine lung carcinomas are separate biological entities are reviewed.
Well-differentiated fetal adenocarcinoma of the lung: clinicopathologic features of 45 cases in China.
WDFA is very different to conventional adenocarcinoma in clinicopathology, it prefers to occur in the second and third decades, and Beta-catenin may be a potential marker for disease.
Comprehensive molecular analysis of genomic profiles and PD-L1 expression in lung adenocarcinoma with a high-grade fetal adenocarcinoma component.
It is indicated that lung cancers with an H-FLAC component rarely harbor currently targetable driver gene mutations for lung cancer but display a high frequency of KMT2C mutations.
High‐grade fetal adenocarcinoma of the lung is a tumour with a fetal phenotype that shows diverse differentiation, including high‐grade neuroendocrine carcinoma: a clinicopathological, immunohistochemical and mutational study of 20 cases
High‐grade fetal adenocarcinoma (H‐FLAC) is a rare variant of pulmonary adenocarcinoma; this study aims to elucidate its clinicopathological features and genetic abnormalities.
Bronchial brushing cytology of a pulmonary fetal adenocarcinoma with a poorly differentiated component
  • K. Kadota, R. Haba, Y. Kushida
  • Medicine
    Cytopathology : official journal of the British Society for Clinical Cytology
  • 2010
The method described here should be compared with commercial LBC in terms of quality and cost, especially as it appears that preparation of cell blocks is often essential to diagnosis in conventional LBC for non-gynaecological cytology.


Fine‐needle aspiration cytology of pulmonary adenocarcinoma of fetal type: Report of a case with lmmunohistochemical and ultrastructural studies
This report describes the fine‐needle aspiration (FNA) cytology of a case of adenocarcinoma resembling fetal lung in a 53‐yr‐old male, a very uncommon malignant tumor of the lung that is similar to
Fine needle aspiration cytology of pulmonary, well‐differentiated fetal adenocarcinoma prepared by the ThinPrep® method
This case report adds to the cytopathology of this tumour sampled by fine needle aspiration and prepared by the ThinPrep method, which is currently classified as a rare subtype of lung adenocarcinoma.
Diagnosis of pulmonary blastoma by fine‐needle aspiration biopsy: Cytologic and immunocytochemical findings
The cell block preparation showed a distinctly biphasic malignant tumor with classic morphologic features of pulmonary blastoma, which underscores the valuable contribution of adequate cell block preparations to accurate diagnosis of fine‐needle aspiration material.
Aberrant Nuclear/Cytoplasmic Localization and Gene Mutation of β-Catenin in Classic Pulmonary Blastoma: β-Catenin Immunostaining Is Useful for Distinguishing Between Classic Pulmonary Blastoma and a Blastomatoid Variant of Carcinosarcoma
This study suggests that β-catenin gene mutations may play a role in the tumorigenesis of CPB and related neoplasms.
Aberrant Nuclear Localization and Gene Mutation of β-catenin in Low-Grade Adenocarcinoma of Fetal Lung Type: Up-Regulation of the Wnt Signaling Pathway May Be a Common Denominator for the Development of Tumors that Form Morules
It is indicated that up-regulating disturbances in the Wnt signaling pathway, including mutation of the β-catenin gene, underlie tumorigenesis of L-FLAC/WDFA and may be a common denominator for the development of tumors with morular formation from a variety of anatomic sites.
Pulmonary adenocarcinomas of the fetal lung type: a clinicopathologic study indicating differences in histology, epidemiology, and natural history of low-grade and high-grade forms.
The H-FLAC represents the prototype of so-called pulmonary blastoma predominantly seen in the elderly, whereas L- FLAC and its biphasic form predominate in the middle-aged population.
Well differentiated fetal adenocarcinoma of the lung in a 29 year old woman
The histological pattern and immunohistochemical profile were consistent with well differentiated fetal adenocarcinoma and the patient made an uneventful postoperative recovery with no recurrence after 18 months.
Pulmonary blastoma with argyrophil cells and lacking sarcomatous features (pulmonary endodermal tumor resembling fetal lung).
A tumor of the lung in a 35-year-old woman contained numerous complex, branching tubules resembling the developing fetal lung in its canalicular state, suggesting an endodermal origin for this neoplasm.
Pulmonary blastoma. Preoperative cytologic and histologic findings.
In eight of the ten cases a preoperative diagnosis of cancer was possible, and in six of them a review of the material disclosed a biphasic feature.
Diagnostic dilemmas in pulmonary cytology
Six cases of lower respiratory tract cytology that presented particular diagnostic challenges or pitfalls in pulmonary cytology are described.