Well‐differentiated fetal adenocarcinoma of the lung: Cytomorphologic features on fine‐needle aspiration with emphasis on use of β‐catenin as a useful diagnostic marker

@article{Proctor2007WelldifferentiatedFA,
  title={Well‐differentiated fetal adenocarcinoma of the lung: Cytomorphologic features on fine‐needle aspiration with emphasis on use of $\beta$‐catenin as a useful diagnostic marker},
  author={L. Proctor and Andrew L Folpe and Annette M. Esper and Linda L. Wolfenden and Seth Daniel Force and Sanjay Logani},
  journal={Diagnostic Cytopathology},
  year={2007},
  volume={35}
}
Well‐differentiated fetal adenocarcinoma (WDFA), also known as low grade adenocarcinoma of the fetal lung type, is a rare pulmonary neoplasm now considered to be a variant of lung adenocarcinoma rather than a type of pulmonary blastoma. Upregulation of the Wnt signaling pathway with subsequent aberrant nuclear/cytoplasmic β‐catenin expression has been recently described in these tumors providing a possible pathogenetic role for this gene in WDFA. We describe the cytomorphologic findings of a… 
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A rare case of well-differentiated fetal adenocarcinoma of the lung that was difficult to diagnose based on radiological evaluations including FDG-PET and intraoperatively diagnosed using frozen section analysis is reported.
A 31-Year-Old Man with Well-differentiated Fetal Adenocarcinoma
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肺胎児型腺癌の 1 例
TLDR
A case of fetal adenocarcinoma of the lung in a 70-year-old woman whose bronchial washing cytology showed many large overlapping palisaded tumor cell clusters is reported, which suggests that fetalAdenocARCinoma shows a variety of clusters in bronchials cytology.
Cytohistology of papillary carcinoid and emerging concept of pulmonary neuroendocrine neoplasms
TLDR
The clinical, cytologic and histologic features of a morphologic variant of pulmonary carcinoid tumor forming exclusively of papillae, and the new findings in cell biology and molecular biology that led to the emerging concept that carcinoids and high‐grade neuroendocrine lung carcinomas are separate biological entities are reviewed.
Well-differentiated fetal adenocarcinoma of the lung: clinicopathologic features of 45 cases in China.
TLDR
WDFA is very different to conventional adenocarcinoma in clinicopathology, it prefers to occur in the second and third decades, and Beta-catenin may be a potential marker for disease.
Comprehensive molecular analysis of genomic profiles and PD-L1 expression in lung adenocarcinoma with a high-grade fetal adenocarcinoma component.
TLDR
It is indicated that lung cancers with an H-FLAC component rarely harbor currently targetable driver gene mutations for lung cancer but display a high frequency of KMT2C mutations.
High‐grade fetal adenocarcinoma of the lung is a tumour with a fetal phenotype that shows diverse differentiation, including high‐grade neuroendocrine carcinoma: a clinicopathological, immunohistochemical and mutational study of 20 cases
High‐grade fetal adenocarcinoma (H‐FLAC) is a rare variant of pulmonary adenocarcinoma; this study aims to elucidate its clinicopathological features and genetic abnormalities.
Bronchial brushing cytology of a pulmonary fetal adenocarcinoma with a poorly differentiated component
  • K. Kadota, R. Haba, Y. Kushida
  • Medicine
    Cytopathology : official journal of the British Society for Clinical Cytology
  • 2010
TLDR
The method described here should be compared with commercial LBC in terms of quality and cost, especially as it appears that preparation of cell blocks is often essential to diagnosis in conventional LBC for non-gynaecological cytology.
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