Weighting in sequence space: a comparison of methods in terms of generalized sequences.

@article{Vingron1993WeightingIS,
  title={Weighting in sequence space: a comparison of methods in terms of generalized sequences.},
  author={Martin Vingron and Peter R. Sibbald},
  journal={Proceedings of the National Academy of Sciences of the United States of America},
  year={1993},
  volume={90 19},
  pages={8777-81}
}
Four methods for weighting aligned biological sequences have recently appeared that differ mathematically, philosophically, and in their results. Thus, while there is consensus about the need to weight sequences, the method to use is contentious. A geometric analysis based on a continuous sequence space is presented that provides a common framework in which to compare the methods. It is concluded that there are two "best" methods. When the sequences are known to be phylogenetically related and… CONTINUE READING

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