Weighted Network-Based Inference of Human MicroRNA-Disease Associations

  title={Weighted Network-Based Inference of Human MicroRNA-Disease Associations},
  author={Qinghua Jiang and Yangyang Hao and Guohua Wang and Tianjiao Zhang and Yadong Wang},
  journal={2010 Fifth International Conference on Frontier of Computer Science and Technology},
The identification of disease microRNAs is vital for understanding the pathogenesis of diseases at the molecular level, and is critical for designing specific molecular tools for diagnosis, treatment and prevention. However, one major issue in microRNA studies is the lack of bioinformatics methods to accurately predict microRNA-disease associations. Herein, we proposed an approach to infer microRNA-disease associations based on a weighted network. We tested our method on benchmark dataset… CONTINUE READING

From This Paper

Figures, tables, and topics from this paper.
6 Citations
52 References
Similar Papers


Publications referenced by this paper.
Showing 1-10 of 52 references


  • Q. Jiang, Y. Wang, Y. Hao, L. Juan, M. Teng
  • Zhang, et al., "miR2Disease: a manually curated…
  • 2009
Highly Influential
4 Excerpts

" miR 2 Disease : a manually curated database for microRNA deregulation in human disease "

  • C. M. Croce
  • Nucleic Acids Res
  • 2009


  • C. Scharfe, H. H. Lu, J. K. Neuenburg, E. A. Allen, G. C. Li
  • Klopstock, et al., "Mapping gene associations in…
  • 2009
1 Excerpt

An analysis of human microRNA and disease associations "

  • J. Teruya-Feldstein L. Ma, R. A. Weinberg
  • PLoS ONE
  • 2008


  • Q. Huang, K. Gumireddy, M. Schrier
  • le Sage, R. Nagel, S. Nair, et al., "The…
  • 2008
1 Excerpt

Down - regulation of microRNA - 1 ( miR - 1 ) in lung cancer . Suppression of tumorigenic property of lung cancer cells and their sensitization to doxorubicin - induced apoptosis by miR - 1 "

  • B. J.
  • J Biol Chem
  • 2008


  • A. Esquela-Kerscher, P. Trang, J. F. Wiggins, L. Patrawala, A. Cheng
  • Ford, et al., "The let-7 microRNA reduces tumor…
  • 2008
1 Excerpt

Similar Papers

Loading similar papers…