Weight loss and reduced body temperature determine humane endpoints in a mouse model of ocular herpesvirus infection.

@article{Hankenson2013WeightLA,
  title={Weight loss and reduced body temperature determine humane endpoints in a mouse model of ocular herpesvirus infection.},
  author={F. Claire Hankenson and Nicholas Ruskoski and Marjorie van Saun and Gui-shuang Ying and Jaewook Oh and Nigel W. Fraser},
  journal={Journal of the American Association for Laboratory Animal Science : JAALAS},
  year={2013},
  volume={52 3},
  pages={277-85}
}
Herpes simplex virus (HSV) has been studied in well-established mouse models to generate latently infected animals for investigations into viral pathogenesis, latency mechanisms, and reactivation. Mice exhibit clinical signs of debilitating infection, during which time they may become severely ill before recovery or die spontaneously. Because the cohort of mice that does survive provides valuable data on latency, there is keen interest in developing methodologies for earlier detection and… CONTINUE READING
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