Weight loss and lipolysis promote a dynamic immune response in murine adipose tissue.

@article{Kosteli2010WeightLA,
  title={Weight loss and lipolysis promote a dynamic immune response in murine adipose tissue.},
  author={Aliki Kosteli and Eiji Sugaru and Guenter Haemmerle and Jayne F. Martin and Jason Lei and Rudolf Zechner and Anthony W. Ferrante},
  journal={The Journal of clinical investigation},
  year={2010},
  volume={120 10},
  pages={3466-79}
}
Obesity elicits an immune response characterized by myeloid cell recruitment to key metabolic organs, including adipose tissue. However, the response of immune cells to nonpathologic metabolic stimuli has been less well studied, and the factors that regulate the metabolic-dependent accumulation of immune cells are incompletely understood. Here we characterized the response of adipose tissue macrophages (ATMs) to weight loss and fasting in mice and identified a role for lipolysis in ATM… CONTINUE READING
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