Weight gain and insulin resistance during nicotine replacement therapy.

  title={Weight gain and insulin resistance during nicotine replacement therapy.},
  author={Abid R Assali and Yitzhak Beigel and R Schreibman and Z Shafer and Menahem Fainaru},
  journal={Clinical cardiology},
  volume={22 5},
BACKGROUND Although the cessation of smoking reduces the increased risk for ischemic heart disease, it is associated with marked weight gain and presumably insulin resistance, both of which heighten the risk of coronary heart disease. HYPOTHESIS We investigated the isolated effect of nicotine on body weight and insulin resistance during smoking cessation. METHODS Eleven healthy, middle-aged heavy smokers were studied. Insulin sensitivity was assessed by an insulin-enhanced, frequently… CONTINUE READING


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