Weight change, genetics and antiepileptic drugs

  title={Weight change, genetics and antiepileptic drugs},
  author={J. Chukwu and N. Delanty and D. Webb and G. Cavalleri},
  journal={Expert Review of Clinical Pharmacology},
  pages={43 - 51}
  • J. Chukwu, N. Delanty, +1 author G. Cavalleri
  • Published 2014
  • Medicine
  • Expert Review of Clinical Pharmacology
  • Weight gain caused by antiepileptic drugs (AEDs) constitutes a serious problem in the management of people with epilepsy. AEDs associated with weight gain include sodium valproate, pregabalin and vigabatrin. Excessive weight gain can lead to non-compliance with treatment and to an exacerbation of obesity-related conditions. The mechanisms by which AEDs cause weight gain are not fully understood. It is likely that weight change induced by some AEDs has a genetic underpinning, and recent… CONTINUE READING
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