Weekly gamma-hydroxybutyrate exposure sensitizes locomotor hyperactivity to low-dose 3,4-methylenedioxymethamphetamine in rats.

@article{Nieuwenhuijzen2009WeeklyGE,
  title={Weekly gamma-hydroxybutyrate exposure sensitizes locomotor hyperactivity to low-dose 3,4-methylenedioxymethamphetamine in rats.},
  author={Petra S. van Nieuwenhuijzen and Kong Ming Li and Glenn E. Hunt and Iain S McGregor},
  journal={Neuropsychobiology},
  year={2009},
  volume={60 3-4},
  pages={195-203}
}
Users of the popular party drug 3,4-methylenedioxymethamphetamine (MDMA) sometimes report combining MDMA with gamma-hydroxybutyrate (GHB) to enhance the pleasurable effects of both drugs. However, very few studies have examined the influences of this drug combination. The present study investigated the development of locomotor sensitization in laboratory rats given 7 once-weekly exposures to either MDMA, GHB or their combination (MDMA/GHB). The drugs were administered at a high ambient… CONTINUE READING
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