Weekly diffusion-weighted imaging of normal-appearing white matter in MS.

@article{Rocca2000WeeklyDI,
  title={Weekly diffusion-weighted imaging of normal-appearing white matter in MS.},
  author={M A Rocca and Mara Cercignani and Giuseppe Iannucci and Giancarlo Comi and Massimo Filippi},
  journal={Neurology},
  year={2000},
  volume={55 6},
  pages={882-4}
}
To elucidate the dynamics and the nature of normal-appearing white matter (NAWM) changes preceding new lesion formation in MS, the authors obtained weekly diffusion-weighted images for 12 weeks from 6 patients. NAWM areas subsequently involved by enhancement had a significant increase in mean diffusivity values starting 6 weeks before the appearance of enhancement (p values ranging between < 0.0001 and 0.04). This suggests that focal edema and demyelination play a part in the NAWM changes… CONTINUE READING

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