Weekly administration of docetaxel (Taxotere): summary of clinical data.

  title={Weekly administration of docetaxel (Taxotere): summary of clinical data.},
  author={John D Hainsworth and Howard A. Burris and Frank Anthony Greco},
  journal={Seminars in oncology},
  volume={26 3 Suppl 10},
Docetaxel (Taxotere; Rhône-Poulence Rorer, Antony, France) is a highly efficacious antineoplastic agent; however, its administration every 3 weeks produces substantial myelosuppression. Based on recent observations that the administration of paclitaxel on a weekly schedule minimizes myelosuppression, investigation of weekly docetaxel has been initiated. A recently completed phase I study of weekly docetaxel demonstrates markedly decreased myelosuppression with this schedule. The maximum… CONTINUE READING


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