Wee1B, Myt1, and Cdc25 function in distinct compartments of the mouse oocyte to control meiotic resumption

Abstract

After a long period of quiescence at dictyate prophase I, termed the germinal vesicle (GV) stage, mammalian oocytes reenter meiosis by activating the Cdc2-cyclin B complex (maturation-promoting factor [MPF]). The activity of MPF is regulated by Wee1/Myt1 kinases and Cdc25 phosphatases. In this study, we demonstrate that the sequestration of components that… (More)
DOI: 10.1083/jcb.200907161

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