Wear debris stimulates bone-resorbing factor expression in the fibroblasts and osteoblasts.

@article{Fujii2011WearDS,
  title={Wear debris stimulates bone-resorbing factor expression in the fibroblasts and osteoblasts.},
  author={Jiro Fujii and Shumpei Niida and Yuji Yasunaga and Akira Yamasaki and Mitsuo Ochi},
  journal={Hip international : the journal of clinical and experimental research on hip pathology and therapy},
  year={2011},
  volume={21 2},
  pages={
          231-7
        }
}
Wear debris is believed to cause periprosthetic osteolysis and loosening of total joint arthroplasties. We investigated the wear debris-mediated osteolysis in wild-type mice and macrophage-deficient Csf1op/Csf1op (op/op) mice using high density polyethylene (HDP) particles transplanted on the parietal bone surface. Four weeks after surgery, phagocytosis of the HDP particles by F4/80-positive macrophages and tartrate-resistant acid phosphatase (TRAP)-positive osteoclasts was observed in the… CONTINUE READING

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