Weal and flare responses to intradermal rocuronium and cisatracurium in humans.

@article{Levy2000WealAF,
  title={Weal and flare responses to intradermal rocuronium and cisatracurium in humans.},
  author={Jerrold H Levy and M Gottge and Fania Szlam and Rashid Zaffer and Catherine McCall},
  journal={British journal of anaesthesia},
  year={2000},
  volume={85 6},
  pages={844-9}
}
Thirty volunteers underwent intradermal skin testing with increasing concentrations of rocuronium and cisatracurium to evaluate weal and flare responses, and whether either agent would cause mast cell degranulation and sensitization upon re-exposure. We found that intradermal injection of rocuronium and cisatracurium at concentrations > 10(-4) M resulted in positive weal (>8 mm) responses, and positive flare responses at > 10(-4) and > 10(-5) M respectively. Only cisatracurium caused mild to… CONTINUE READING

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