Weak organic acid stress triggers hyperphosphorylation of the yeast zinc-finger transcription factor War1 and dampens stress adaptation.

@article{Frohner2010WeakOA,
  title={Weak organic acid stress triggers hyperphosphorylation of the yeast zinc-finger transcription factor War1 and dampens stress adaptation.},
  author={Ingrid E. Frohner and Christa Gregori and Dorothea Anrather and Elisabeth Roitinger and Christoph Sch{\"u}ller and Gustav Ammerer and Karl Kuchler},
  journal={Omics : a journal of integrative biology},
  year={2010},
  volume={14 5},
  pages={575-86}
}
Exposure of Saccharomyces cerevisiae to weak organic acids such as sorbate, propionate, or benzoate rapidly induces the plasma membrane ABC transporter Pdr12, requiring the Zn(II)(2)Cys(6) zinc-finger transcription factor War1. Weak acid stress rapidly triggers War1 phosphorylation but its role for War1 function is not clear yet. Here, we provide new insights into sorbate-induced phosphorylation of War1. A War1 zinc-finger mutant is still hyperphosphorylated in response to sorbate stress… CONTINUE READING