Weak inhibitors protect cholinesterases from strong inhibitors (paraoxon): in vitro effect of tiapride.

@article{Petroianu2005WeakIP,
  title={Weak inhibitors protect cholinesterases from strong inhibitors (paraoxon): in vitro effect of tiapride.},
  author={Georg A Petroianu and Mohamed Yousif Hasan and Kholoud Arafat and Syed Muhammad Nurulain and Andrea Schmitt},
  journal={Journal of applied toxicology : JAT},
  year={2005},
  volume={25 6},
  pages={562-7}
}
Weak and reversible inhibitors of cholinesterases, when administered before potent organophosphorus inhibitors (pretreatment), have the ability, to a certain extent, to protect enzymes from inhibition. Such a protective effect was demonstrated in vitro for metoclopramide and ranitidine. The putative mode of protective action of these substances is, when administered in excess, competition for the active site of the enzyme with the more potent organophosphate. The present paper presents results… CONTINUE READING