Weak functional constraints on phosphoproteomes.

@article{Landry2009WeakFC,
  title={Weak functional constraints on phosphoproteomes.},
  author={Christian R. Landry and Emmanuel D. Levy and Stephen W. Michnick},
  journal={Trends in genetics : TIG},
  year={2009},
  volume={25 5},
  pages={193-7}
}
Owing to their crucial roles in regulating protein function, phosphorylation sites (phosphosites) are expected to be evolutionarily conserved. However, mixed results regarding this prediction have been reported. We resolve these contrasting conclusions to show that phosphosites are, on average, more conserved than non-phosphorylated equivalent residues when their enrichment in disordered regions of proteins is taken into account. Phosphosites of known function are dramatically more conserved… CONTINUE READING

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