Weak functional constraints on phosphoproteomes.

  title={Weak functional constraints on phosphoproteomes.},
  author={Christian R. Landry and Emmanuel D. Levy and Stephen W. Michnick},
  journal={Trends in genetics : TIG},
  volume={25 5},
Owing to their crucial roles in regulating protein function, phosphorylation sites (phosphosites) are expected to be evolutionarily conserved. However, mixed results regarding this prediction have been reported. We resolve these contrasting conclusions to show that phosphosites are, on average, more conserved than non-phosphorylated equivalent residues when their enrichment in disordered regions of proteins is taken into account. Phosphosites of known function are dramatically more conserved… CONTINUE READING

From This Paper

Figures, tables, and topics from this paper.


Publications citing this paper.
Showing 1-10 of 122 extracted citations


Publications referenced by this paper.
Showing 1-10 of 24 references

Non - functional phosphorylations ?

  • R. Malik
  • Trends Biochem . Sci .
  • 2008

methods for protein sequences: empirical Bayesian methods are superior

  • Collins, M.O
  • Mol. Biol. Evol
  • 2008

Similar Papers

Loading similar papers…