Weak force stalls protrusion at the leading edge of the lamellipodium.

@article{Bohnet2006WeakFS,
  title={Weak force stalls protrusion at the leading edge of the lamellipodium.},
  author={Sophie Bohnet and Revathi Ananthakrishnan and Alex Mogilner and Jean-Jacques Meister and Alexander B. Verkhovsky},
  journal={Biophysical journal},
  year={2006},
  volume={90 5},
  pages={1810-20}
}
Protrusion, the first step of cell migration, is driven by actin polymerization coupled to adhesion at the cell's leading edge. Polymerization and adhesive forces have been estimated, but the net protrusion force has not been measured accurately. We arrest the leading edge of a moving fish keratocyte with a hydrodynamic load generated by a fluid flow from a micropipette. The flow arrests protrusion locally as the cell approaches the pipette, causing an arc-shaped indentation and upward folding… CONTINUE READING