Weak binding affinity of human 4EHP for mRNA cap analogs.

@article{uberek2007WeakBA,
  title={Weak binding affinity of human 4EHP for mRNA cap analogs.},
  author={Joanna Żuberek and Dorota Kubacka and Agnieszka Jablonowska and Jacek Jemielity and Janusz Stępiński and Nahum Sonenberg and Edward Darzynkiewicz},
  journal={RNA},
  year={2007},
  volume={13 5},
  pages={691-7}
}
Ribosome recruitment to the majority of eukaryotic mRNAs is facilitated by the interaction of the cap binding protein, eIF4E, with the mRNA 5' cap structure. eIF4E stimulates translation through its interaction with a scaffolding protein, eIF4G, which helps to recruit the ribosome. Metazoans also contain a homolog of eIF4E, termed 4EHP, which binds the cap structure, but not eIF4G, and thus cannot stimulate translation, but it instead inhibits the translation of only one known, and possibly… CONTINUE READING

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To understand why 4EHP does not inhibit general translation , we studied the binding affinity of 4EHP for cap analogs using two methods : fluorescence titration and stopped - flow measurements .
To understand why 4EHP does not inhibit general translation , we studied the binding affinity of 4EHP for cap analogs using two methods : fluorescence titration and stopped - flow measurements .
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