Weak alignment NMR: a hawk-eyed view of biomolecular structure.

  title={Weak alignment NMR: a hawk-eyed view of biomolecular structure.},
  author={Adriaan Bax and Alexander Grishaev},
  journal={Current opinion in structural biology},
  volume={15 5},
Imposing a very slight deviation from the isotropic random distribution of macromolecules in solution in an NMR sample tube permits the measurement of residual internuclear dipolar couplings (RDCs). Such interactions are very sensitive functions of the time-averaged orientation of the corresponding internuclear vectors and thereby offer highly precise structural information. In recent years, advances have been made both in the technology to measure RDCs and in the computational procedures that… CONTINUE READING
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