Weak acids may act as teratogens by accumulating in the basic milieu of the early mammalian embryo

@article{Nau1986WeakAM,
  title={Weak acids may act as teratogens by accumulating in the basic milieu of the early mammalian embryo},
  author={Heinz Nau and William J. Scott},
  journal={Nature},
  year={1986},
  volume={323},
  pages={276-278}
}
Among the eleven drugs or chemicals which are well-documented human teratogens, eight (or their main metabolites) are weak acids whereas none is a weak base. Moreover, 23 out of 32 acids tested have been found to be teratogenic in at least one animal species1. The acidic property of drugs may therefore be an important determinant of teratogenicity. We demonstrate here that the intracellular pH (pHi) of the mouse and rat embryo is higher than that of maternal plasma, as determined by the… CONTINUE READING

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