Weak Negative and Positive Selection and the Drift Load at Splice Sites

Abstract

Splice sites (SSs) are short sequences that are crucial for proper mRNA splicing in eukaryotic cells, and therefore can be expected to be shaped by strong selection. Nevertheless, in mammals and in other intron-rich organisms, many of the SSs often involve nonconsensus (Nc), rather than consensus (Cn), nucleotides, and beyond the two critical nucleotides… (More)
DOI: 10.1093/gbe/evu100

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@inproceedings{Denisov2014WeakNA, title={Weak Negative and Positive Selection and the Drift Load at Splice Sites}, author={Stepan V. Denisov and Georgii A. Bazykin and Roman A. Sutormin and Alexander V. Favorov and Andrey A. Mironov and Mikhail S. Gelfand and Alexey S. Kondrashov}, booktitle={Genome biology and evolution}, year={2014} }