Weak D and DEL alleles detected by routine SNaPshot genotyping: identification of four novel RHD alleles

@article{Silvy2011WeakDA,
  title={Weak D and DEL alleles detected by routine SNaPshot genotyping: identification of four novel RHD alleles},
  author={Monique Silvy and Sophie Simon and Julia Gouvitsos and Julie Di Cristofaro and Virginie Ferrera and Jacques Chiaroni and Pascal Bailly},
  journal={Transfusion},
  year={2011},
  volume={51}
}
BACKGROUND: Molecular RHD blood group typing is very efficient for managing donors and patients carrying any of the various molecular types of weak D and DEL. The purpose of the work was to develop a multiplex polymerase chain reaction (PCR) SNaPshot assay for simultaneous detection of weak D and DEL alleles that are prevalent in Europeans, Africans, and Asians. 

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TLDR
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TLDR
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D antigen variants may be grouped into partial D, weak D, and DEL types. Cumulative phenotype frequencies of these D variants may approach 1% in certain European regions. Unambiguous and quick

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TLDR
The RhD blood group system exemplifies a genotype‐phenotype correlation by virtue of its highly polymorphic and immunogenic nature and is thought to result from missense mutations leading to quantitative change of the D antigen in the red blood cell membrane or intracellularly.

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