Water sorption/desorption--near IR and calorimetric study of crystalline and amorphous raffinose.

@article{Hogan2001WaterSI,
  title={Water sorption/desorption--near IR and calorimetric study of crystalline and amorphous raffinose.},
  author={Sarah E. Hogan and Graham Buckton},
  journal={International journal of pharmaceutics},
  year={2001},
  volume={227 1-2},
  pages={57-69}
}
Mass loss at elevated RH is an established method for determining the occurrence of crystallisation of an amorphous material. Through the combination of near infrared spectroscopy and gravimetric vapour sorption, it has been possible to show the transition of raffinose from its spray-dried amorphous form to a crystalline form without this characteristic mass loss. It has also been possible to observe changes in the crystalline material for a period of 30 h subsequent to exposure to elevated… CONTINUE READING

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