Water-soluble coenzyme Q10 formulation (Q-TER®) in the treatment of presbycusis

  title={Water-soluble coenzyme Q10 formulation (Q-TER{\textregistered}) in the treatment of presbycusis},
  author={Angelo Salami and Renzo Mora and Massimo Dellepiane and Giorgio Manini and Valentina Santomauro and Luciano Barettini and Luca Guastini},
  journal={Acta Oto-Laryngologica},
  pages={1154 - 1162}
Abstract Conclusion: These preliminary data are encouraging for a larger clinical trial to collect additional evidence on the effect of Q-TER® in preventing the development of hearing loss in subjects with presbycusis. Objectives: The purpose of this study was to evaluate the efficiency and applicability of a water-soluble formulation of CoQ10 (Q-TER®) in subjects with presbycusis. Methods: A total of 60 patients with presbycusis were included and divided into three numerically equal groups… 

Water-soluble coenzyme Q10 formulation in presbycusis: Long-term effects

Abstract Conclusion: These findings provide the basis for understanding the duration of the effect after the last use of the drug and encourage a larger clinical trial to collect additional evidence

Coenzyme Q10 plus Multivitamin Treatment Prevents Cisplatin Ototoxicity in Rats

The Acu-Qter treatment was able to prevent and completely neutralize ototoxicity in rats treated with three daily Cpt doses, supporting the synergic protective effects of coenzyme Q terclatrate and Acuval 400® against Cpt-induced oxidative stress.

Protective Effects of Silymarin Against Age-Related Hearing Loss in an Aging Rat Model

It is indicated that silymarin with doses of 100 and 200 mg/kg/day has protective effect against ARHL and it can be supplemented into the diet of older people to slow down the progression of age-related hearing loss.

Role of antioxidants in prevention of age-related hearing loss: a review of literature

Age-related hearing loss (ARHL), also known as presbycusis, is one of the most prevalent chronic degenerative conditions. It is characterized by a decline in auditory function. ARHL is caused by the

Mitochondria-Targeted Antioxidants for Treatment of Hearing Loss: A Systematic Review

Protective effects of MitoQ and SkQR1 against ototoxicity have been previously evaluated in animal models and/or mouse auditory cell lines and high-quality clinical trials are required to reveal the therapeutic effect of mitochondria-targeted antioxidants in terms of otoprotection in patients.

Water-soluble CoQ10 as A Promising Anti-aging Agent for Neurological Dysfunction in Brain Mitochondria

Efforts to develop strategies to enhance the biological availability of CoQ10 to successfully ameliorate age-related brain mitochondrial dysfunction or neurodegenerative disorders may provide a promising anti-aging agent.

Simvastatin Results in a Dose-Dependent Toxic Effect on Spiral Ganglion Neurons in an In Vitro Organotypic Culture Assay

A neurotoxic effect of simvastatin on SGNs in vitro is suggested, which seems to be at least partially mediated by the mevalonate pathway, and caution is warranted to use simVastatin as a potential otoprotective drug.

A Population-Based Study on the Association between Statin Use and Sudden Sensorineural Hearing Loss

This study found that SSNHL was significantly associated with previous statin use, and the relationship of regular and irregular statin users with SSN Hockey was explored.

Toward Cochlear Therapies.

This review begins by recapitulating current understanding of the molecular pathways that underlie cochlear sensorineural damage, as well as the survival signaling pathways that can provide endogenous protection and tissue rescue, and guides the reader through to the recent discoveries in pharmacological, gene and cell therapy research towards hearing protection and restoration.

Role of Oxidative Stress and Antioxidants in Acquired Inner Ear Disorders

This review focuses on the relationship between acquired hearing loss and antioxidant use to provide an overview of novel antioxidants, namely medicines, supplemental nutrients, and natural foods, based on clinical, animal, and cultured-cell studies.



Effect of water-soluble coenzyme Q10 on noise-induced hearing loss in guinea pigs

The results of this study indicate that coenzyme Q10 reduces cochlear oxidative stress induced by acoustic overstimulation and increases antioxidative activity in the cochlea, as measured by analysis of hydroxy radical scavenging activity by electron spin resonance.

The monitoring role of otoacoustic emissions and oxidative stress markers in the protective effects of antioxidant administration in noise-exposed subjects: a pilot study.

  • A. FetoniM. Garzaro C. Giordano
  • Medicine
    Medical science monitor : international medical journal of experimental and clinical research
  • 2009
This pilot study confirms that DPOAEs represent a sensitive test for monitoring the effects of noise in preclinical conditions and pharmacological treatment.

Coenzyme Q 10 and Cardiovascular Risk Factors in Idiopathic Sudden Sensorineural Hearing Loss Patients

  • G. CadoniS. Scipione S. Lippa
  • Medicine
    Otology & neurotology : official publication of the American Otological Society, American Neurotology Society [and] European Academy of Otology and Neurotology
  • 2007
This is the first report regarding the association of ISSNHL and low serum levels of the antioxidant CoQ and low levels of CoQ remained significantly associated with a high risk of sudden sensorineural hearing loss.

Safety assessment of coenzyme Q10 (CoQ10)

The use of CoQ10 as a dietary supplement has grown with a corresponding increase in daily dosage, and its physiological function is to act as an essential cofactor for ATP production, and to perform important antioxidant activities in the body.

Molecular mechanisms of glutamate neurotoxicity in mixed cultures of NT2‐derived neurons and astrocytes: Protective effects of coenzyme Q10

A model of the complex interactions between neurons and astrocytes in regulating glutamate metabolism is presented, suggesting a useful role for coenzyme Q10 in treatments of neurological diseases associated with glutamate excitotoxicity.

The prognostic value of speech recognition scores at diagnosis of vestibular schwannoma

Central nicotinic receptors, neurotrophic factors and neuroprotection

Age at onset of geriatric depression and sensorineural hearing deficits