Water quality objectives for mixtures of toxic chemicals: problems and perspectives.

@article{Vighi2003WaterQO,
  title={Water quality objectives for mixtures of toxic chemicals: problems and perspectives.},
  author={Marco Vighi and Rolf Altenburger and Asa Arrhenius and Thomas Backhaus and Wolfgang Boedeker and Hans Blanck and Federica Consolaro and M. S. John B. Faust and Antonio Finizio and Klaus Froehner and Paola Gramatica and L. Horst Grimme and Frederick Gr{\"o}nvall and V Hamer and Martin Scholze and Helge A Walter},
  journal={Ecotoxicology and environmental safety},
  year={2003},
  volume={54 2},
  pages={139-50}
}
The need to develop water quality objectives not only for single substances but also for mixtures of chemicals seems evident. For that purpose, the conceptual basis could be the use of the two existing biometric models: concentration addition (CA) and independent action (IA), which is also called response addition. Both may allow calculation of the toxicity of mixtures of chemicals with similar modes of action (CA) or dissimilar modes of action (IA), respectively. The joint research project… CONTINUE READING