Water migration from soft gelatin capsule shell to fill material and its effect on drug solubility.

@article{Serajuddin1986WaterMF,
  title={Water migration from soft gelatin capsule shell to fill material and its effect on drug solubility.},
  author={Abu T M Serajuddin and Pai-ching Sheen and Matthew A. Augustine},
  journal={Journal of pharmaceutical sciences},
  year={1986},
  volume={75 1},
  pages={62-4}
}
The bioavailability of some poorly water-soluble drugs was reported to increase due to a change in dosage form from a tablet to a solution encapsulated in soft gelatin capsules. However, the objective of increasing the bioavailability may be defeated if the drug crystallizes from a solution inside the capsule. In this study, a water-insoluble drug [alpha-pentyl-3-(2-quinolinylmethoxy)benzenemethanol; REV 5901] was solubilized in both polyethylene glycol 400 (PEG 400) and a 6:1 mixture of… CONTINUE READING

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