Water-dependent reaction pathways: an essential factor for the catalysis in HEPD enzyme.

@article{Du2012WaterdependentRP,
  title={Water-dependent reaction pathways: an essential factor for the catalysis in HEPD enzyme.},
  author={Likai Du and Jun Gao and Yongjun Liu and Chengbu Liu},
  journal={The journal of physical chemistry. B},
  year={2012},
  volume={116 39},
  pages={11837-44}
}
The hydroxyethylphosphonate dioxygenase (HEPD) catalyzes the critical carbon-carbon bond cleavage step in the phosphinothricin (PT) biosynthetic pathway. The experimental research suggests that water molecules play an important role in the catalytic reaction process of HEPD. This work proposes a water involved reaction mechanism where water molecules serve… CONTINUE READING